2001-07-21 Daniel Santos tdraw 1 Antonio Margarito, Ruben Rodriguez Coliseum, Bayamon, Puerto Rico - WBO

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2001-07-21 Daniel Santos tdraw 1 Antonio Margarito, Ruben Rodriguez Coliseum, Bayamon, Puerto Rico - WBO. Referee: Jose Rivera. After just 131 seconds, and following two terrible head clashes that left the challenger badly cut, the fight was called off and announced as a no-decision under the Association of Boxing Commission Rules. For our purposes it should be seen as a technical draw. The first coming together of heads occurred when Margarito (146), working his way in to back the southpaw champion on the ropes, was cut over the right eye. Although the referee allowed it to go on, when Margarito dipped under a Santos (147) left cross moments later before inadvertently bringing his head up the second clash of heads occurred. At that point, with blood pouring from a deep wound, the fight was stopped by the referee following a discussion with the doctor.

Before a rematch could be made, Santos relinquished the WBO version of the title in November in order to step up and challenge for the vacant WBO junior middleweight title. That was eventually followed by an announcement that Margarito would fight Antonio Diaz to decide the vacant title.