Evander Holyfield vs. Michael Moorer (1st meeting)
1994-04-22 : Michael Moorer 214 lbs beat Evander Holyfield 214 lbs by MD in round 12 of 12
- Location: Caesars Palace, Las Vegas, Nevada, USA
- Referee: Mills Lane
- Judge: Jerry Roth 115-114
- Judge: Chuck Giampa 116-112
- Judge: Dalby Shirley 114-114
- World Boxing Association Heavyweight Title (1st defense of 2nd reign by Holyfield)
- International Boxing Federation Heavyweight Title (1st defense of 2nd reign by Holyfield)
- See also: Evander Holyfield vs. Michael Moorer II
- Holyfield was a 2 to 1 favorite. 
- This was Holyfield's first bout with Don Turner as his trainer, who also served as his cutman. Holyfield dismissed his longtime cutman, Ace Marotta, rather than pay him $25,000 to be in his corner. 
- Holyfield dropped Moorer with a left hook late in the second round, a round which Moorer was winning decisively. Judge Jerry Roth scored the round 10-10. If he had scored the round 10-9 for Holyfield, his score would have been 114-114 and Holyfield would have retained the title with a majority draw. Holyfield's manager, Shelly Finkel, filed a protest with the commission over the second round scoring. 
- Moorer opened a cut over Holyfield's left eye in round five.
- Moorer landed 262 of 558 punches (47%) and Holyfield landed 159 of 529 (30%).
- Ed Schuyler Jr. of the Associated Press scored the fight 118-111 for Moorer.
- HBO unofficial judge Harold Lederman scored the fight 114-113 for Holyfield.
- Holyfield was hospitalized after the fight. He was suffering from dehydration and a rotator-cuff injury. A kidney bruise was also discovered. He was given a large amount of liquids for the kidney problem, but his lungs filled because his heart was not able to pump the fluids out. He was then diagnosed as having a noncompliant left ventricle. Holyfield retired as a result.  A couple of months later, Holyfield said he had been cured by evangelist Benny Hinn.  Holyfield went to the Mayo Clinic and was given a clean bill of health. He was told the heart condition appeared because he was over-medicated and over-hydrated in the treatment he received after the Moorer fight.  Years later, Dr. Margaret Goodman, former chairman of the medical advisory board of the Nevada State Athletic Commission, said the medical arm of the commission questioned Holyfield about possible HGH use. "There were questions [because] the abnormalities Evander had with his heart were findings that could have been consistent with growth hormone use," she said. "The problem was there was no test and Evander denied any use of growth hormone."