Seth Mitchell vs. Chazz Witherspoon
2012-04-28 : Seth Mitchell 241½ lbs beat Chazz Witherspoon 231½ lbs by TKO at 2:31 in round 3 of 12
- Location: Boardwalk Hall, Atlantic City, New Jersey, USA
- Referee: Randy Neumann
- Judge: Alan Rubenstein
- Judge: John Stewart
- Judge: Waleska Roldan
- Ring Announcer: Joe Martinez
- Aired On: HBO World Championship Boxing
- NABO Heavyweight Title (vacant)
- Seth Mitchell 24-0-1 (18 KOs) vs. Chazz Witherspoon 30-2 (22 KOs)
- Fight was on the undercard of Bernard Hopkins vs. Chad Dawson (2nd meeting).
- Witherspoon entered as a 5.5/1 betting underdog. 
Mansour vs. Guinn
| NABO Heavyweight Title Fight
# 31 (vacant)
Witherspoon moved around early in the opening round, working behind a jab. He hurt Mitchell midway through the round with a right hand and connected with a few more. Mitchell, despite being on wobbly legs, was able to hold on and keep his feet. Mitchell had a much-improved 2nd Round with more aggression as Witherspoon moved less and was more willing to exchange. Mitchell worked well to the body and caught Witherspoon with some power punches. A left hook put Witherspoon on his backside in the first 30 seconds of Round 3. He was up at the count of six. Mitchell came forward and was able to pin Witherspoon against the ropes and land some clean right hands. At this, the referee stepped in and began counting as if he was going to give a standing eight-count before waving and end to the bout.
- "This was my toughest fight to date. I knew Chazz would bring it. He had me dazed in the first and second rounds. I knew he was going to try and come and get me. My trainer told me to never get away from my body shots and it paid off with big dividends." Seth Mitchell in the post-fight interview with Max Kellerman
- To quote HBO boxing analyst Emanuel Steward during third round action: "Mitchell is very, very strong, it seems like he's turned the fight around on his football mentality." In the post-fight analysis Steward said "I'm very impressed (with Mitchell). He's what you look for in a heavyweight...In fact, he's what really would make the heavyweight division come back--having a fighter like him."
- This was the first time that two African American heavyweights with college degrees stepped into the ring against each other in a major bout. Witherspoon received a degree in Pharmaceutical Marketing from St. Joseph's University in Philadelphia in 2005 and Mitchell, who attended Michigan State on a football scholarship, earned a degree in Criminal Justice in 2006.
- Mitchell entered the ring wearing a Michigan State shirt with "Bleed Green" on the front and "Train like you fight" on the back. He was wearing trunks that had his Michigan State football #48 and a Michigan State Spartan logo on them. Mitchell played linebacker for Michigan State and turned to boxing after a knee injury forced him to give up football.