BoxRec

1. Shane Mosley (whole different Mosley than fought Mayweather, Pacquiao and Canelo, beat him in close, but attractive fight)
2. Sergio Martinez (Sergio seems not so good as in past but still, Cotto decisively beat long time middleweight champion at that night)
3. Zab Judah (decisively beat and KO top welterweight at the Garden before hostile crowd, negativum of this fight are low blows)
4. Antonio Margarito rematch (schooled and stopped this guy, sweet revenge, previous fight ends at TKO loss woth plaster controversy)
5. Joshua Clottey (won a close fight, but with massive bleeding, like a boss )

Please, name your top 5

In no particular order, in my opinion of his most meaningful wins, not necessarily most prestigious:

Mosley
Malignaggii
Torres
Corley
Clottey

damn i forgot Ricardo Torres

Here I go again...you guys are proving my point that Cotto is the most overrated fighter in the history of the sport. He's beaten two guys that are worth putting on the list and that's Mosley and Sergio. Mosley had just got nabbed with roids and is another overrated fighter who's lost to everyone unless he was juiced up and he shouldn't get ANY credit for beating Sergio who was almost 40 fighting on one knee. Anyone would have beaten Sergio that night. But everyone wants to talk about how he's a HOF'er. PLEASE.

You would have a better list if you asked for the top 5 guys that have beaten Cotto:

1. Floyd Mayweather Jr.
2. Manny Pacquaio
3. Austin Trout
4. Antonio Marguarto (hands of stone)
5. His Mama

Compare that list with his top 5 wins and tell me why he's a HOF'er.