Leo Santa Cruz vs. Carl Frampton (2nd meeting)
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Carl Frampton 125 lbs lost to Leo Santa Cruz 125 lbs by MD in round 12 of 12
- Date: 2017-01-28
- Location: MGM Grand, Las Vegas, Nevada, USA
- Referee: Kenny Bayless
- Judge: Burt A Clements 114-114
- Judge: Glenn Feldman 113-115
- Judge: Dave Moretti 113-115
- World Boxing Association Super World Featherweight Title (1st defense by Frampton)
- Ring Announcer: Jimmy Lennon Jr.
- Aired On: Showtime (Main Event)
- Santa Cruz wins majority decision over Frampton to regain his world title and the BoxRec number one worldwide ratings position.
- First loss by Frampton in 24 bouts.