So, I'm betting on a Chisora win because:
Vitali's dominance is a potential weakness. Eh? Well, the way I see it, he's had so many cakewalks and pushovers that he's forgotten what a real fight feels like. If Dereck can test him, Vitali may have to search within himself, only to find the well of fighting spirit he needs is empty.
A fit Chisora is relentless. The last thing a forty something giant with a history of injuries needs is someone who won't let him rest. Vitali is used to controlling the pace. He won't be comfortable with Chisora constantly chasing him down, forcing him to throw punches.
Chisora's crafty defence and punch resistance mean he'll be able to spend more time in range than Vitali's previous opponents, giving him the opportunity to land his own shots. And because Chisora will be right there on top of him, Vitali's normal trick of leaning back out of harm's way will be less effective.
Vitali's sparring is unlikely to prepare him for Chisora's key punch in this fight - the RIGHT hook round the side of the guard. Chisora has had great success with this shot against Sexton and Helenius and I expect him to score repeatedly with it against Vitali. The Ukrainian won't be used to getting cuffed with shots like this and will become confused and disoriented.
Thanks to the Helenius experience, fighting a giant on his home turf won't faze Chisora or his camp. Dereck is relishing the chance to upset the odds in front of Vitali's fans.
Mind games. Chisora's assessment of Vitali as a playground bully isn't too far off the mark. Vitali knows Chisora isn't scared of him. The comments about "swinging both ways" surprised Klitschko - in fact the whole head to head was full of surprises for an intelligent man who'd thought he'd heard it all before. Klitschko isn't quite sure what to expect from Chisora, and that chink of uncertainty can carry through into the ring.
Prediction: Chisora KO 9