If you can trust find a company that can trust who will guarantee you tickets it will be much less of a headache but i would say that as i run Queensbury Travel and i've already got the packages ready to go.
www.QueensburyTravel.com
I took over 100 people over with me for Mayweather v De La Hoya and got tickets for all of them (which wasn't easy let me tell you) and then did the same for Hatton v Mayweather.
Not booking the flights to NY until you know where it will be isn't a bad idea but you probably won't really save anything as the one stop flights will probably cost no more than the NY flight plus an internal flight.
Where to stay will depend on how much you want to spend and if you want the full on Vegas experience. Staying at the MGM is like sitting on a boxing world conveyor belt, you'll see everyone in the lobby, bars, lifts etc. For Mayweather v DLH my room was a few doors away from Tito Trinidad's.
You can stay a few minutes off Strip for a fraction of the price and you'll hardly be spending any time in your room anyway.
Getting there is the easy part concentrate on your strategy for getting a ticket in your hand. Don't rely on getting on Ticketmaster.com the second they go on sale either.
I've been to Vegas 8 times in the last 4 years so pile in with any questions.
Jon